• Vasoactive substances are released from injured tissue -» cause (+)inc in capillary permeability
• Extensive burns -» generalized body edema & (-)dec circulating intravascular blood volume
• Fluid loss -» (-)dec organ perfusion
• (+)inc pulse, (-)dec blood pressure, (-) cardiac output 

Initially:

• Hyponatremia & hyperkalemia occur 
• (+)inc hematocrit level = d/t plasma loss
• Then falls to below normal by 3rd-4th day d/t RBC damage 
• Blood shuts blood from the kidney -» causing oliguria 
• Body reabsorbs fluid and diuresis excess fluid over next days-weeks
• (-)dec blood flow to GI tract -» intestinal ileus & GI dysfunction
• Immune system depression -» immunosuppression
• (+)inc risk of infection & sepsis
• Pulmonary HTN can develop -» may result in (-)dec arterial oxygen tension level & (-)dec lung compliance